Behavioral Medication Information

In some locations and circumstances, child psychiatry consultations are difficult to obtain. For some children and adolescents with ID and behavior problems, the medical home may be the only avenue for treatment. While the following information may be helpful, it is not exhaustive information regarding these medications. The clinician should also refer to standard sources for additional information. [Ashworth: 2008]

Atypical Antipsychotics

Antipsychotics in general: Do baseline CMP, fasting glucose, lipids. Check BMI. Too much can be a problem – too little can be a problem. Watch for akathisia, dystonia (Can treat with cogentin or benadryl). Can exacerbate diabetes.
Risperdal: Approved for “irritability syndrome” in autistic children ages 5-16 by FDA. This might include aggression and self-injurious behavior. Avoid heroic dosing. Start low 0.25 mg QHS or BID and increase slowly.
Qutiepine (Seroquel): Start 25 mg BID up to 800 mg daily (upper limit in adults) in divided doses. Patients may not like anxiolytic “feel.”
Olanzapine (Zyprexa): Start 2.5 to 5 mg daily up to 30 mg (upper limit in adults) daily. Sedation and weight gain are biggest problems.
Aripiprazole (Abilify): Start 2.5 to 5 mg daily up to 20-30 mg (upper limit in adults). Can be activating. Doesn’t appear to affect prolactin levels.
Zipraxidone (Geodon): Start 20-40 mg BID up to 80 mg BID (upper limit in adults). Weight neutral. Can prolong QT, so get baseline EKG.

Other Medications


Clonazepam: Start 0.25 mg BID and increase.


Concerta: Begin 18 mg daily and increase. Medium dose is about 1 mg/kg/day, light dose is 0.5 mg/kg/day.

Central Alpha-adrenergic Agonists

Clonidine: BID to TID dosing. Sedating. Start 0.05 to 0.1 mg BID. Need to taper. Patch available.


Author: James Ashworth, MD - 9/2008
Reviewing Author: Meghan Candee, MD - 4/2015
Content Last Updated: 5/2015

Page Bibliography

Ashworth J.
Challenges in treating mental illness in the developmentally disabled population.
Biologic Basis Seminar, 2008; Park City, UT.
Dr. Ashworth provided a lecture with information about medications used in behavior management.