- Hyperphagia or overeating beginning in early childhood (between 1-6 years)
- Decreased physical activity relating to decreased muscle tone and quantity, and increased fat mass
- Reduced metabolic rate (about 60% of normal) related to decreased muscle mass
- An inability to vomit
- Heart failure
- Thrombophlebitis and chronic leg edema
- Ulcers and cellulitis
- Orthopedic problems
- Abnormal lipid profiles
- Diabetes mellitus, type II
- Obstructive sleep apnea
- Narrowing of the airway
- Impaired respiratory function
- High carbon dioxide levels
- Increased risks of complications with general anesthesia
- Weight control through diet restriction (about 60% of normal daily caloric intake)
- Exercise programs tailored to the individual and depending on health status, age, and jointly established goals
- Hormone therapy, including growth hormone therapy which leads to increased height, decreased fat mass and increased muscle mass, and increased metabolic rate, and sex hormone therapy
Genetics in Primary Care Institute (AAP)
The goal of this site is to increase collaboration in the care of children with known or suspected genetic disorders. Includes health supervision guidelines and other useful resources; a collaboration among the Health Resources & Services Administration, the Maternal and Child Health Bureau, and the American Academy of Pediatrics.
|Author:||Merlin G. Butler, MD, PhD - 9/2008|
|Content Last Updated:||11/2014|
Holsen LM, Zarcone JR, Brooks WM, Butler MG, Thompson TI, Ahluwalia JS, Nollen NL, Savage CR.
Neural mechanisms underlying hyperphagia in Prader-Willi syndrome.
Obesity (Silver Spring). 2006;14(6):1028-37. PubMed abstract / Full Text
Miller J, Kranzler J, Liu Y, Schmalfuss I, Theriaque DW, Shuster JJ, Hatfield A, Mueller OT, Goldstone AP, Sahoo T, Beaudet
AL, Driscoll DJ.
Neurocognitive findings in Prader-Willi syndrome and early-onset morbid obesity.
J Pediatr. 2006;149(2):192-8. PubMed abstract